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KMID : 1039420160500010067
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Journal of Pathology and Translational Medicine
2016 Volume.50 No. 1 p.67 ~ p.70
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IgG4-Related Disease Presented as a Mural Mass in the Stomach
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Woo Chang-Gok
Yook Jeong-Hwan
Kim Ah-Young
Kim Ji-Hun
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Abstract
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Isolated gastric IgG4-related disease (IgG4-RD) is a very rare tumefactive inflammatory condition, with only a few cases reported to date. A 48-year-old woman was incidentally found to have a subepithelial tumor in the stomach. Given a presumptive diagnosis of gastrointestinal stromal tumor or neuroendocrine tumor, she underwent wedge resection. The lesion was vaguely nodular and mainly involved the submucosa and proper muscle layer. Microscopically, all classical features of type I autoimmune pancreatitis including lymphoplasmacytic infiltration, storiform fibrosis, obliterative phlebitis, and numerous IgG4-positive plasma cells were seen. She had no evidence of IgG4-RD in other organs. Although very rare, IgG4-RD should be considered one of the differential diagnoses in the setting of gastric wall thickening or subepithelial mass-like lesion. Deep biopsy with awareness of this entity might avoid unnecessary surgical intervention.
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KEYWORD
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Immunoglobulin G4, Stomach, Autoimmune diseases, Granuloma, plasma cell
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